Differential genome-wide DNA methylation patterns in childhood obesity.

ABSTRACT:

Objective

Exposure to stress during pregnancy may program susceptibility to the development of obesity in offspring. Our goal was to determine whether prenatal maternal stress (PNMS) due to a natural disaster was associated with child obesity, and to compare the DNA methylation profiles in obese versus non-obese children at age 13½ years. Women and their children were involved in the longitudinal natural disaster study-Project Ice Strom, which served as a human model to study PNMS. Blood was collected from 31 children (including five obese children). Infinium HumanMethylation450 BeadChip Array was performed for genome-wide DNA methylation analyses.

Results

Results demonstrated a well-defined obesity-associated genome-wide DNA methylation pattern. There were 277 CpGs, corresp

SUBMITTER: Cao-Lei L 

PROVIDER: S-EPMC6434834 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature