Linc01194 acts as an oncogene in colorectal carcinoma and is associated with poor survival outcome.

ABSTRACT:

Background

The incidence of colorectal cancer ranks among the top three malignant tumors, attributing to more than 50,000 deaths in the United States every year. Survival rate is directly correlated with TNM stage at diagnosis, and identifying the molecules involved in the cancer development process will provide directions to better investigate the mechanisms of colorectal cancer.

Materials and methods

Bioinformatics analysis of differentially expressed long noncoding RNAs (lncRNAs), survival analysis, cell proliferation assay, migration assay, and Western blot analysis were performed.

Results

Fifty-one lncRNAs were identified between the early stage and late-stage groups. In the survival analysis, we found that Linc01194 is correlated with poor survival of colon canc

SUBMITTER: Wang X 

PROVIDER: S-EPMC6434913 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature