Chlamydia trachomatis infection in primary fallopian tube and high-grade serous ovarian cancers: a pilot study.

ABSTRACT:

Background

The aim of this study was to evaluate the association of Chlamydia trachomatis (CT) infection with primary tubal and high-grade serous ovarian cancers.

Methods

This is a cross-sectional, retrospective study conducted at Ain Shams University Maternity Hospital, Egypt, from February 2008 to October 2017. Sixty-seven paraffin archival blocks specimens were retrieved from cases who underwent staging laparotomy due to high-grade serous ovarian cancer (30 cases), primary tubal serous cancer (25 cases), and control specimens of (12) tubal specimens from cases of benign gynecological conditions. All samples were examined for CT DNA using semiquantitative qRT-PCR.

Results

CT DNA was detected in 84% of high-grade tubal serous cancer, 16.7% of high-grade serous

SUBMITTER: Laban M 

PROVIDER: S-EPMC6434919 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature