Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure.

ABSTRACT: Midlife obesity is a risk factor of late onset Alzheimer's disease (LOAD) but why this is the case remains unknown. As systemic inflammation is involved in both conditions, obesity-related neuroinflammation may contribute to damage in limbic structures important in LOAD. Here, we investigated the hypothesis that systemic inflammation would mediate central obesity related effects on limbic tissue microstructure in 166 asymptomatic individuals (38-71 years old). We employed MRI indices sensitive to myelin and neuroinflammation [macromolecular proton fraction (MPF) and k_f] from quantitative magnetization transfer (qMT) together with indices from neurite orientation dispersion and density imaging (NODDI) to investigate the effects of central adiposity on the fornix, parahippocampal

SUBMITTER: Metzler-Baddeley C 

PROVIDER: S-EPMC6435101 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature