Single particle trajectories reveal active endoplasmic reticulum luminal flow.

ABSTRACT: The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory proteins and delivery of functional solutes throughout the cell^1,2. Molecular mobility through the ER network enables these functionalities, but diffusion alone is not sufficient to explain luminal transport across supramicrometre distances. Understanding the ER structure-function relationship is critical in light of mutations in ER morphology-regulating proteins that give rise to neurodegenerative disorders^3,4. Here, super-resolution microscopy and analysis of single particle trajectories of ER luminal proteins revealed that the topological organization of the ER correlates with distinct trafficking modes of its luminal content: with a dom

SUBMITTER: Holcman D 

PROVIDER: S-EPMC6435195 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature