Adenosine deaminase for diagnosis of tuberculous pleural effusion: A systematic review and meta-analysis.

ABSTRACT: OBJECTIVE:Pleural fluid adenosine deaminase (ADA) is a useful diagnostic test for tuberculous pleural effusion (TPE), but its exact threshold and accuracy in clinical decision-making is unclear. We aimed to assess diagnostic performance of ADA in TPE and to clarify its optimal diagnostic threshold. METHODS:We searched PubMed, Embase, and Cochrane Library databases for articles indexed up to October 2018. We included English language studies that provided both sensitivity and specificity of ADA in TPE diagnosis. Summary estimates for sensitivity and specificity were obtained through bivariate random effects model, both overall and at prespecified threshold ranges of <36, 40±4, 45-65 and >65 IU/L. RESULTS:We retrieved 2162 citations, and included 174 publications with 27009 patients. All stu

SUBMITTER: Aggarwal AN 

PROVIDER: S-EPMC6435228 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature