A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions.

ABSTRACT: West Nile virus (WNV), a member of the Flavivirus genus, is a leading cause of viral encephalitis in the United States¹. The development of neutralizing antibodies against the flavivirus envelope (E) protein is critical for immunity and vaccine protection². Previously identified candidate therapeutic mouse and human neutralizing monoclonal antibodies (mAbs) target epitopes within the E domain III lateral ridge and the domain I-II hinge region, respectively³. To explore the neutralizing antibody repertoire elicited by WNV infection for potential therapeutic application, we isolated ten mAbs from WNV-infected individuals. mAb WNV-86 neutralized WNV with a 50% inhibitory concentration of 2 ng ml^-1, one of the most potently neutralizing flavivirus-sp

SUBMITTER: Goo L 

PROVIDER: S-EPMC6435290 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature