High-Sensitivity Cardiac Troponin T Improves the Diagnosis of Perioperative MI.

ABSTRACT:

Background

The diagnosis of myocardial infarction (MI) after noncardiac surgery has traditionally relied on using relatively insensitive contemporary cardiac troponin (cTn) assays. We hypothesized that using a recently introduced novel high-sensitivity cTnT (hscTnT) assay would increase the detection rate of perioperative MI.

Methods

In this ancillary study of the Vitamins in Nitrous Oxide trial, readjudicated incidence rates of myocardial injury (new isolated cTn elevation) and MI were compared when diagnosed by contemporary cTnI versus hscTnT. We probed various relative (eg, >50%) or absolute (eg, +5 ng/L) hscTnT change metrics. Inclusion criteria for this ancillary study were the presence of a baseline and at least 1 postoperative hscTnT value.

Results

Among 605 pa

SUBMITTER: Brown JC 

PROVIDER: S-EPMC6435292 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature