miR-146a C/G polymorphism increased the risk of head and neck cancer, but overall cancer risk: an analysis of 89 studies.

ABSTRACT: Several studies have evaluated the association of miR-146a C/G with head and neck cancer (HNC) susceptibility, and overall cancer risk, but with inconclusive outcomes. To drive a more precise estimation, we carried out this meta-analysis. The literature was searched from MEDLINE (mainly PubMed), Embase, the Cochrane Library, and Google Scholar databases to identify eligible studies. A total of 89 studies were included. The results showed that miR-146a C/G was significantly associated with increased HNC risk in dominant model (I² =15.6%, P_{heterogeneity}=0.282, odds ratio (OR) =1.088, 95% confidence interval (CI) =1.002-1.182, P=0.044). However, no cancer risk was detected under all genetic models. By further stratified analysis, we fou

SUBMITTER: Sun D 

PROVIDER: S-EPMC6435476 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature