Propofol infusion syndrome: a structured literature review and analysis of published case reports.

ABSTRACT: Propofol infusion syndrome is a rare, potentially fatal condition first described in children in the 1990s and later reported in adults. We provide a narrative review of what is currently known about propofol infusion syndrome, including a structured analysis of all published case reports; child and adult cases were analysed separately as propofol is no longer used for long-term sedation in children. The review contains an update on current knowledge of the pathophysiology of this condition along with recommendations for its diagnosis, prevention, and management. We reviewed 108 publications documenting 168 cases of propofol infusion syndrome. We evaluated clinical features and analysed factors influencing mortality in child and adult cases using separate multivariate analysis models. We u

SUBMITTER: Hemphill S 

PROVIDER: S-EPMC6435842 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature