Nanofibers Regulate Single Bone Marrow Stem Cell Osteogenesis via FAK/RhoA/YAP1 Pathway.

ABSTRACT: Understanding cell-material interactions is a prerequisite for the development of bio-inspired materials for tissue regeneration. While nanofibrous biomaterials have been widely used in tissue regeneration, the effects of nanofibrous architecture on stem cell behaviors are largely ambiguous because the previous biomaterial systems used for nanofiber-cell interactions could not exclude the interference of cell-cell interactions. In this study, we developed a unique micropatterning technology to confine one single stem cell in a microisland of the nanofibrous micropatterned matrix; therefore, eliminating any potential intercellular communications. The nanofibrous micropatterned matrix, which mimicked both the physical architecture and chemical composition of natural extracellular matrix, was

SUBMITTER: Chang B 

PROVIDER: S-EPMC6436105 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature