Dataset Information

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.

ABSTRACT:

Background

Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to be overexpressed in colorectal, hepatocellular, lung and breast carcinomas. The expression profile of Tomm34 in ovarian cancer has not been investigated. Therefore, the aim of the current study was to investigate the expression pattern of Tomm34 in ovarian carcinomas and analyse its correlation with clinico-pathological parameters.

Results

Epithelial ovarian cancers (140) were histologically classified based on their morphology and graded into two types comprising 5 histologic subgroups. Type I carcinomas comprise low grade serous (LGSC), clear cell (CCOC) and endometrioid (ENOC), type II comprises high grade serous carcinomas (HGSC) and solid, pseudoendometrioid, transitional carcinomas (SET). Tomm34 was more highly expressed in type II than type I carcinomas (p < 0.0001). Comparing tumours based on the mutation in the TP53 gene revealed similar results, where mutant tumours exhibited significantly higher levels of Tomm34 (p < 0.0001). The decreased levels of Tomm34 in type I carcinomas were particularly evident in clear cell and mucinous carcinomas. The expression of Tomm34 was also positively correlated with FIGO stage (r = 0.23; p = 0.007). Tomm34 levels also indicated poor prognosis for patients with mutant p53.

Conclusions

Our data indicate that Tomm34 is commonly expressed at high levels in epithelial ovarian cancers, except for the clear cell and mucinous subtypes. The expression of Tomm34 corresponds with the dualistic model of ovarian cancer pathogenesis where high grade, type II tumours exhibit higher expression of Tomm34 in contrast to type I tumours. These data are also comparable to the previous findings that Tomm34 is a marker of progression and poor prognosis in human cancer.

SUBMITTER: Muller P

PROVIDER: S-EPMC6436220 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.

Muller Petr P Coates Philip J PJ Nenutil Rudolf R Trcka Filip F Hrstka Roman R Chovanec Josef J Brychtova Veronika V Vojtesek Borivoj B

Journal of ovarian research 20190327 1

<h4>Background</h4>Increased activity of the chaperones Hsp70 and Hsp90 is a common feature of solid tumours. Translocase of the outer mitochondrial membrane 34 (Tomm34) is a cochaperone of both Hsp70 and Hsp90 that was found to be overexpressed in colorectal, hepatocellular, lung and breast carcinomas. The expression profile of Tomm34 in ovarian cancer has not been investigated. Therefore, the aim of the current study was to investigate the expression pattern of Tomm34 in ovarian carcinomas and ...[more]

PMID: 30917858

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Dataset Information

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.

Background

Results

Conclusions

Publications

Tomm34 is commonly expressed in epithelial ovarian cancer and associates with tumour type and high FIGO stage.

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