Plasm YKL-40 Levels Are Associated with Hypertension in Patients with Obstructive Sleep Apnea.

ABSTRACT:

Background

Obstructive sleep apnea (OSA) is a common disease. It can cause many serious complications. OSA may increase the risk of hypertension. However, the exact mechanism of OSA causing hypertension is not fully understood. YKL-40/chitinase-3-like protein-1 plays an important role in vascular injury, repair, and generation. We sought to explore the role of YKL-40 in endothelial dysfunction and hypertension in OSA patients.

Methods

All subjects were examined by polysomnography (PSG) and the expression of YKL-40 in the plasm of the subjects was measured by luminex. Carotid intima-media thickness (CIMT) was measured by B-mode ultrasound.

Results

According to the conditions of OSA and hypertension, we studied four groups of 157 subjects, including OSA group (OSA, N=77

SUBMITTER: Li K 

PROVIDER: S-EPMC6436335 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature