Chemical Modifications in the Life of an mRNA Transcript.

ABSTRACT: Investigations over the past eight years of chemical modifications on messenger RNA (mRNA) have revealed a new level of posttranscriptional gene regulation in eukaryotes. Rapid progress in our understanding of these modifications, particularly, N⁶-methyladenosine (m⁶A), has revealed their roles throughout the life cycle of an mRNA transcript. m⁶A methylation provides a rapid mechanism for coordinated transcriptome processing and turnover that is important in embryonic development and cell differentiation. In response to cellular signals, m⁶A can also regulate the translation of specific pools of transcripts. These mechanisms can be hijacked in human diseases, including numerous cancers and viral infection. Beyond m⁶A, many other mRNA m

SUBMITTER: Nachtergaele S 

PROVIDER: S-EPMC6436393 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature