Toxoplasma-Induced Hypermigration of Primary Cortical Microglia Implicates GABAergic Signaling.

ABSTRACT: Toxoplasma gondii is a widespread obligate intracellular parasite that causes chronic infection and life-threatening acute infection in the central nervous system. Previous work identified Toxoplasma-infected microglia and astrocytes during reactivated infections in mice, indicating an implication of glial cells in acute toxoplasmic encephalitis. However, the mechanisms leading to the spread of Toxoplasma in the brain parenchyma remain unknown. Here, we report that, shortly after invasion by T. gondii tachyzoites, parasitized microglia, but not parasitized astrocytes, undergo rapid morphological changes and exhibit dramatically enhanced migration in 2-dimensional and 3-dimensional matrix confinements. Interestingly, primary microglia secreted the neurotransmitte

SUBMITTER: Bhandage AK 

PROVIDER: S-EPMC6436526 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature