Association Between Titin Loss-of-Function Variants and Early-Onset Atrial Fibrillation.

ABSTRACT:

Importance

Atrial fibrillation (AF) is the most common arrhythmia affecting 1% of the population. Young individuals with AF have a strong genetic association with the disease, but the mechanisms remain incompletely understood.

Objective

To perform large-scale whole-genome sequencing to identify genetic variants related to AF.

Design, setting, and participants

The National Heart, Lung, and Blood Institute's Trans-Omics for Precision Medicine Program includes longitudinal and cohort studies that underwent high-depth whole-genome sequencing between 2014 and 2017 in 18 526 individuals from the United States, Mexico, Puerto Rico, Costa Rica, Barbados, and Samoa. This case-control study included 2781 patients with early-onset AF from 9 studies and identified 4959 controls o

SUBMITTER: Choi SH 

PROVIDER: S-EPMC6436530 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature