Early-life gut microbiome and egg allergy.

ABSTRACT:

Background

Gut microbiota may play a role in egg allergy. We sought to examine the association between early-life gut microbiota and egg allergy.

Methods

We studied 141 children with egg allergy and controls from the multicenter Consortium of Food Allergy Research study. At enrollment (age 3 to 16 months), fecal samples were collected, and clinical evaluation, egg-specific IgE measurement, and egg skin prick test were performed. Gut microbiome was profiled by 16S rRNA sequencing. Analyses for the primary outcome of egg allergy at enrollment, and the secondary outcomes of egg sensitization at enrollment and resolution of egg allergy by age 8 years, were performed using Quantitative Insights into Microbial Ecology, Phylogenetic Investigation of Communities by Reconstruction of

SUBMITTER: Fazlollahi M 

PROVIDER: S-EPMC6436531 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature