Prenatal high molecular weight phthalates and bisphenol A, and childhood respiratory and allergic outcomes.

ABSTRACT:

Background

The prevalence of asthma and allergy is increasing in US children. In utero exposure to chemicals used in personal care products and plastics may contribute to increase in these diseases.

Methods

We quantified urinary concentrations of eight phthalate metabolites and bisphenol A in mothers twice during pregnancy in 1999-2000 in Salinas, California. We assessed probable asthma, aeroallergies, eczema, and spirometry in their children at age 7, and measured T helper 1 and T helper 2 cells in blood at ages 2, 5, and 7 (N = 392). We employed Bayesian model averaging to select confounders from additional biomarkers measured in this population and controlled for them in logistic and linear regressions.

Results

Monocarboxyisooctyl phthalate was associated with incr

SUBMITTER: Berger K 

PROVIDER: S-EPMC6436539 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature