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Real-time interactive simulations of large-scale systems on personal computers and cell phones: Toward patient-specific heart modeling and other applications.

ABSTRACT: Cardiac dynamics modeling has been useful for studying and treating arrhythmias. However, it is a multiscale problem requiring the solution of billions of differential equations describing the complex electrophysiology of interconnected cells. Therefore, large-scale cardiac modeling has been limited to groups with access to supercomputers and clusters. Many areas of computational science face similar problems where computational costs are too high for personal computers so that supercomputers or clusters currently are necessary. Here, we introduce a new approach that makes high-performance simulation of cardiac dynamics and other large-scale systems like fluid flow and crystal growth accessible to virtually anyone with a modest computer. For cardiac dynamics, this approach will allow not only scientists and students but also physicians to use physiologically accurate modeling and simulation tools that are interactive in real time, thereby making diagnostics, research, and education available to a broader audience and pushing the boundaries of cardiac science.

SUBMITTER: Kaboudian A

PROVIDER: S-EPMC6436932 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Real-time interactive simulations of large-scale systems on personal computers and cell phones: Toward patient-specific heart modeling and other applications.

Kaboudian Abouzar A Cherry Elizabeth M EM Fenton Flavio H FH

Science advances 20190327 3

Cardiac dynamics modeling has been useful for studying and treating arrhythmias. However, it is a multiscale problem requiring the solution of billions of differential equations describing the complex electrophysiology of interconnected cells. Therefore, large-scale cardiac modeling has been limited to groups with access to supercomputers and clusters. Many areas of computational science face similar problems where computational costs are too high for personal computers so that supercomputers or ...[more]

PMID: 30944861

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Project description:BackgroundAutomatically detecting falls with mobile phones provides an opportunity for rapid response to injuries and better knowledge of what precipitated the fall and its consequences. This is beneficial for populations that are prone to falling, such as people with lower limb amputations. Prior studies have focused on fall detection in able-bodied individuals using data from a laboratory setting. Such approaches may provide a limited ability to detect falls in amputees and in real-world scenarios.ObjectiveThe aim was to develop a classifier that uses data from able-bodied individuals to detect falls in individuals with a lower limb amputation, while they freely carry the mobile phone in different locations and during free-living.MethodsWe obtained 861 simulated indoor and outdoor falls from 10 young control (non-amputee) individuals and 6 individuals with a lower limb amputation. In addition, we recorded a broad database of activities of daily living, including data from three participants' free-living routines. Sensor readings (accelerometer and gyroscope) from a mobile phone were recorded as participants freely carried it in three common locations-on the waist, in a pocket, and in the hand. A set of 40 features were computed from the sensors data and four classifiers were trained and combined through stacking to detect falls. We compared the performance of two population-specific models, trained and tested on either able-bodied or amputee participants, with that of a model trained on able-bodied participants and tested on amputees. A simple threshold-based classifier was used to benchmark our machine-learning classifier.ResultsThe accuracy of fall detection in amputees for a model trained on control individuals (sensitivity: mean 0.989, 1.96*standard error of the mean [SEM] 0.017; specificity: mean 0.968, SEM 0.025) was not statistically different (P=.69) from that of a model trained on the amputee population (sensitivity: mean 0.984, SEM 0.016; specificity: mean 0.965, SEM 0.022). Detection of falls in control individuals yielded similar results (sensitivity: mean 0.979, SEM 0.022; specificity: mean 0.991, SEM 0.012). A mean 2.2 (SD 1.7) false alarms per day were obtained when evaluating the model (vs mean 122.1, SD 166.1 based on thresholds) on data recorded as participants carried the phone during their daily routine for two or more days. Machine-learning classifiers outperformed the threshold-based one (P<.001).ConclusionsA mobile phone-based fall detection model can use data from non-amputee individuals to detect falls in individuals walking with a prosthesis. We successfully detected falls when the mobile phone was carried across multiple locations and without a predetermined orientation. Furthermore, the number of false alarms yielded by the model over a longer period of time was reasonably low. This moves the application of mobile phone-based fall detection systems closer to a real-world use case scenario.

Dataset Information

Real-time interactive simulations of large-scale systems on personal computers and cell phones: Toward patient-specific heart modeling and other applications.

Publications

Real-time interactive simulations of large-scale systems on personal computers and cell phones: Toward patient-specific heart modeling and other applications.

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