Neural correlates of distinct cognitive phenotypes in early Parkinson's disease.

ABSTRACT: OBJECTIVE:Cognitive decline is common in Parkinson's disease (PD), but changes can occur in a variety of cognitive domains. The lack of a single cognitive phenotype complicates diagnosis and tracking. In an earlier study we used a data-driven approach to identify distinct cognitive phenotypes of early PD. Here we identify the morphometric brain differences between those different phenotypes compared with cognitively normal PD participants. METHODS:Six different cognitive classes were included (Weak, Typical, Weak-Visuospatial/Strong-Memory, Weak-Visuospatial, Amnestic, Strong). Structural differences between each class and the Typical class were assessed by deformation-based morphometry. RESULTS:The different groups evidenced different patterns of atrophy. Weak class had frontotemporal and

SUBMITTER: Bayram E 

PROVIDER: S-EPMC6436969 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature