Optimized dual-time-window protocols for quantitative [¹⁸F]flutemetamol and [¹⁸F]florbetaben PET studies.

ABSTRACT:

Background

A long dynamic scanning protocol may be required to accurately measure longitudinal changes in amyloid load. However, such a protocol results in a lower patient comfort and scanning efficiency compared to static scans. A compromise can be achieved by implementing dual-time-window protocols. This study aimed to optimize these protocols for quantitative [¹⁸F]flutemetamol and [¹⁸F]florbetaben studies.

Methods

Rate constants for subjects across the Alzheimer's disease spectrum (i.e., non-displaceable binding potential (BP_ND) in the range 0.02-0.77 and 0.02-1.04 for [¹⁸F]flutemetamol and [¹⁸F]florbetaben, respectively) were established based on clinical [¹⁸F]flutemetamol (N = 6) and [¹⁸F]florb

SUBMITTER: Heeman F 

PROVIDER: S-EPMC6437225 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature