Maternal and fetal intrauterine tissue crosstalk promotes proinflammatory amplification and uterine transition†.

ABSTRACT: Birth is a complex biological event requiring genetic, cellular, and physiological changes to the uterus, resulting in a uterus activated for completing the physiological processes of labor. We define the change from the state of pregnancy to the state of parturition as uterine transitioning, which requires the actions of inflammatory mediators and localized paracrine interactions between intrauterine tissues. Few studies have examined the in vitro interactions between fetal and maternal gestational tissues within this proinflammatory environment. Thus, we designed a co-culture model to address this gap, incorporating primary term human myometrium smooth muscle cells (HMSMCs) with human fetal membrane (hFM) explants to study interactions between the tissues. We hypothesized that crosstalk

SUBMITTER: Leimert KB 

PROVIDER: S-EPMC6437267 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature