Quercetin inhibits intestinal non-haem iron absorption by regulating iron metabolism genes in the tissues.

ABSTRACT:

Purpose

There is general agreement that some dietary polyphenols block non-haem iron uptake, but the mechanisms by which they achieve this action are poorly understood. Since the polyphenol quercetin is ingested daily in significant amounts, we have investigated the effect of quercetin on duodenal non-haem iron absorption in vivo, as well as its effect on factors known to be involved in systemic iron metabolism.

Methods

Rats were subject to gastric gavage and systemic quercetin administration. Treatments were followed with uptake studies using radiolabeled iron, serum iron and transferrin saturation measurements, LC-MS/MS analysis of quercetin metabolites in serum, determination of tissue non-haem iron content and analysis of gene expression of iron-related proteins.

Resu

SUBMITTER: Lesjak M 

PROVIDER: S-EPMC6437293 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature