Prospective associations of dietary carbohydrate, fat, and protein intake with β-cell function in the CODAM study.

ABSTRACT:

Purpose

Type 2 diabetes mellitus (T2DM) is characterized by both impaired pancreatic β-cell function (BCF) and insulin resistance. In the etiology of T2DM, BCF basically determines whether a person with a certain degree of insulin resistance develops T2DM, as β-cells are able to compensatorily increase insulin secretion. The effects of dietary intake on BCF are largely unknown. Our study aim was to investigate whether dietary macronutrient intake predicts BCF.

Methods

Prospective data (median follow-up 7 years) of 303 individuals recruited from the CODAM study population (aged 40-70 years, 39% women) were analyzed. BCF was measured by C-peptide deconvolution and physiological modeling of data from a 5-point, 75-g, 2-h oral glucose tolerance test. Macronutrient intake was est

SUBMITTER: den Biggelaar LJCJ 

PROVIDER: S-EPMC6437317 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature