Impaired Junctions and Invaded Macrophages in Oral Epithelia With Oral Pain.

ABSTRACT: Recurrent or chronic oral pain is a great burden for patients. Recently, the links between epithelial barrier loss and disease were extended to include initiation and propagation. To explore the effects of pathohistological changes in oral epithelia on pain, we utilized labial mucosa samples in diagnostic labial gland biopsies from patients with suspected Sjögren's syndrome (SS), because they frequently experience pain and discomfort. In most labial mucosa samples from patients diagnosed with SS, disseminated epithelial cellular edema was prevalent as ballooning degeneration. The disrupted epithelia contained larger numbers of infiltrating macrophages in patients with oral pain than in patients without pain. Immunohistochemistry revealed that edematous areas were distinct from normal areas

SUBMITTER: Yoshimoto RU 

PROVIDER: S-EPMC6437346 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature