Nonsaponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression.

ABSTRACT:

Background

Ginsenosides of Korean Red Ginseng extracts (RGE) and its saponin components suppress secretion of inflammasome-mediating cytokines, whereas the nonsaponin fraction (NS) of RGE oppositely stimulates cytokine secretion. Although direct exposure of NS to macrophages in mice induces cytokine production, oral administration of NS has not been studied in inflammasome-related disease in animal models.

Methods

Mice were fed RGE or NS for 7 days and then developed peritonitis. Peritoneal cytokines were measured, and peritoneal exudate cells (PECs) were collected to assay expression levels of a set of toll-like receptors (TLRs) and cytokines in response to NS ingestion. In addition, the role of intestinal bacteria in NS-fed mice was assessed. The effect of preexposure to N

SUBMITTER: Ahn H 

PROVIDER: S-EPMC6437451 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature