Molecular Basis for the Potent Inhibition of the Emerging Carbapenemase VCC-1 by Avibactam.

ABSTRACT: In 2016, we identified a new class A carbapenemase, VCC-1, in a nontoxigenic Vibrio cholerae strain that had been isolated from retail shrimp imported into Canada for human consumption. Shortly thereafter, seven additional VCC-1-producing V. cholerae isolates were recovered along the German coastline. These isolates appear to have acquired the VCC-1 gene (bla_VCC-1) independently from the Canadian isolate, suggesting that bla_VCC-1 is mobile and widely distributed. VCC-1 hydrolyzes penicillins, cephalothin, aztreonam, and carbapenems and, like the broadly disseminated class A carbapenemase KPC-2, is only weakly inhibited by clavulanic acid or tazobactam. Although VCC-1 has yet to be observed in the clinic, its encroachment into aquaculture an

SUBMITTER: Mangat CS 

PROVIDER: S-EPMC6437526 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature