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Conjugal Transfer, Whole-Genome Sequencing, and Plasmid Analysis of Four mcr-1-Bearing Isolates from U.S. Patients.

ABSTRACT: Four Enterobacteriaceae clinical isolates bearing mcr-1 gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to Escherichia coli; plasmids were stable in conjugants after multiple passages on nonselective media. mcr-1 was located on an IncX4 (n = 3) or IncN (n = 1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate that the mcr-1-bearing plasmids in this study were highly transferable in vitro and stable in the recipients.

SUBMITTER: Zhu W 

PROVIDER: S-EPMC6437532 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Conjugal Transfer, Whole-Genome Sequencing, and Plasmid Analysis of Four <i>mcr-1</i>-Bearing Isolates from U.S. Patients.

Zhu Wenming W   Lawsin Adrian A   Lindsey Rebecca L RL   Batra Dhwani D   Knipe Kristen K   Yoo Brian B BB   Perry K Allison KA   Rowe Lori A LA   Lonsway David D   Walters Maroya S MS   Rasheed J Kamile JK   Halpin Alison Laufer AL  

Antimicrobial agents and chemotherapy 20190327 4

Four <i>Enterobacteriaceae</i> clinical isolates bearing <i>mcr-1</i> gene-harboring plasmids were characterized. All isolates demonstrated the ability to transfer colistin resistance to <i>Escherichia coli</i>; plasmids were stable in conjugants after multiple passages on nonselective media. <i>mcr-1</i> was located on an IncX4 (<i>n</i> = 3) or IncN (<i>n</i> = 1) plasmid. The IncN plasmid harbored 13 additional antimicrobial resistance genes. Results indicate that the <i>mcr-1</i>-bearing pla  ...[more]

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