Immunomodulatory ECM-like Microspheres for Accelerated Bone Regeneration in Diabetes Mellitus.

ABSTRACT: Bone repair and regeneration process is markedly impaired in diabetes mellitus (DM) that affects hundreds of millions of people worldwide. As a chronic inflammatory disease, DM creates a proinflammatory microenvironment in defective sites. Most of the studies on DM-associated bone regeneration, however, neglect the importance of immunomodulation under the DM condition and adopt the same approaches to normal bone healing, leading to limited bone healing. In this study, we developed a unique bioinspired injectable microsphere as an osteoimmunomodulatory biomaterial that modulates macrophages to create a prohealing microenvironment under the DM condition. The microsphere was self-assembled with heparin-modified gelatin nanofibers, and interleukin 4 (IL4) was incorporated into the nanofibrous

SUBMITTER: Hu Z 

PROVIDER: S-EPMC6437671 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature