Ontology highlight
ABSTRACT:
SUBMITTER: Liu P
PROVIDER: S-EPMC6437812 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Liu Peng P Chen Xiangling X Zhu Jianming J Li Bo B Chen Zhaoqiang Z Wang Guimin G Sun Haiguo H Xu Zhijian Z Zhao Zhixin Z Zhou Chen C Xie Chengying C Lou Liguang L Zhu Weiliang W
ChemistryOpen 20190328 3
Heat shock protein 90 (Hsp90) is a potential oncogenic target. However, Hsp90 inhibitors in clinical trial induce heat shock response, resulting in drug resistance and inefficiency. In this study, we designed and synthesized a series of novel triazine derivatives (<b>A1</b>-<b>26</b>, <b>B1</b>-<b>13</b>, <b>C1</b>-<b>23</b>) as Hsp90 inhibitors. Compound <b>A14</b> directly bound to Hsp90 in a different manner from traditional Hsp90 inhibitors, and degraded client proteins, but did not induce t ...[more]