Metabolic engineering of Ashbya gossypii for deciphering the de novo biosynthesis of γ-lactones.

ABSTRACT:

Background

Lactones are highly valuable cyclic esters of hydroxy fatty acids that find application as pure fragrances or as building blocks of speciality chemicals. While chemical synthesis often leads to undesired racemic mixtures, microbial production allows obtaining optically pure lactones. The production of a specific lactone by biotransformation depends on the supply of the corresponding hydroxy fatty acid, which has economic and industrial value similar to γ-lactones. Hence, the identification and exploration of microorganisms with the rare natural ability for de novo biosynthesis of lactones will contribute to the long-term sustainability of microbial production. In this study, the innate ability of Ashbya gossypii for de novo production of γ-lactones from glucose was evalu

SUBMITTER: Silva R 

PROVIDER: S-EPMC6437850 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature