Reprogramming histone modification patterns to coordinate gene expression in early zebrafish embryos.

ABSTRACT:

Background

Multicellular organisms require precise gene regulation during ontogeny, and epigenetic modifications, such as DNA methylation and histone modification, facilitate this precise regulation. The conservative reprogramming patterns of DNA methylation in vertebrates have been well described. However, knowledge of how histone modifications are passed on from gametes to early embryos is limited, and whether histone modification reprogramming is conserved is not clear.

Results

We profiled H3K4me3/H3K27me3 modifications in gametes and early embryos in zebrafish and found that the patterns in gene promoter regions have been largely set to either co-occupied or active states in gametes and then passed on to early embryos. Co-occupied states are partially maintained, while a

SUBMITTER: Zhu W 

PROVIDER: S-EPMC6437866 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature