Case-control Indian buffet process identifies biomarkers of response to Codrituzumab.

ABSTRACT:

Background

Codrituzumab, a humanized monoclonal antibody against Glypican-3 (GPC3), which is expressed in hepatocellular carcinoma (HCC), was tested in a randomized phase II trial in advanced HCC patients who had failed prior systemic therapy. Biomarker analysis was performed to identify a responder population that benefits from treatment.

Methods

A novel statistical method based on the Indian buffet process (IBP) was used to identify biomarkers predictive of response to treatment with Codrituzumab. The IBP is a novel method that allows flexibility in analysis design, and which is sensitive to slight, but meaningful between-group differences in biomarkers in very complex datasets RESULTS: The IBP model identified several subpopulations of patients having defined biomarker va

SUBMITTER: Pradier MF 

PROVIDER: S-EPMC6438135 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature