Plasma protein adsorption on Fe₃O₄-PEG nanoparticles activates the complement system and induces an inflammatory response.

ABSTRACT:

Background

Understanding of iron oxide nanoparticles (IONP) interaction with the body milieu is crucial to guarantee their efficiency and biocompatibility in nanomedicine. Polymer coating to IONP, with polyethyleneglycol (PEG) and polyvinylpyrrolidone (PVP), is an accepted strategy to prevent toxicity and excessive protein binding.

Aim

The aim of this study was to investigate the feature of IONP adsorption of complement proteins, their activation and consequent inflammatory response as a strategy to further elucidate their biocompatibility.

Methods

Three types of IONP with different surface characteristics were used: bare (IONP-bare), coated with PVP (IONP-PVP) and PEG-coated (IONP-PEG). IONPs were incubated with human plasma and adsorbed proteins were identified. BAL

SUBMITTER: Escamilla-Rivera V 

PROVIDER: S-EPMC6438142 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature