Ontology highlight
ABSTRACT:
SUBMITTER: Smith RG
PROVIDER: S-EPMC6438205 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Alzheimer's & dementia : the journal of the Alzheimer's Association 20180315 12
<h4>Introduction</h4>Alzheimer's disease is a neurodegenerative disorder that is hypothesized to involve epigenetic dysregulation of gene expression in the brain.<h4>Methods</h4>We performed an epigenome-wide association study to identify differential DNA methylation associated with neuropathology in prefrontal cortex and superior temporal gyrus samples from 147 individuals, replicating our findings in two independent data sets (N = 117 and 740).<h4>Results</h4>We identify elevated DNA methylati ...[more]