Muscle-specific Perilipin2 down-regulation affects lipid metabolism and induces myofiber hypertrophy.

ABSTRACT:

Background

Perilipin2 (Plin2) belongs to a family of five highly conserved proteins, known for their role in lipid storage. Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes. An association between Plin2 and lower muscle mass and strength has been found in elderly and inactive people, but its function in skeletal muscle is still unclear. Here, we addressed the role of Plin2 in adult muscle by gain and loss of function experiments.

Methods

By mean of in vivo Plin2 down-regulation (shPlin2) and overexpression (overPlin2) in murine tibialis anterior muscle, we analysed the effects of Plin2 genetic manipulations on myofiber size and lipid composition. An analys

SUBMITTER: Conte M 

PROVIDER: S-EPMC6438344 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature