Cachexia induced by cancer and chemotherapy yield distinct perturbations to energy metabolism.

ABSTRACT:

Background

Cancer cachexia is a metabolic disorder involving perturbed energy balance and altered mitochondrial function. Chemotherapy is a primary treatment option for many types of cancer, but there is substantial evidence that some chemotherapeutic agents can also lead to the development and progression of cachexia. In this study, we apply a comprehensive and systems level metabolomics approach to characterize the metabolic perturbations in murine models of cancer-induced and chemotherapy-induced cachexia. Knowledge of the unique pathways through which cancer and chemotherapy drive cachexia is necessary in order to develop effective treatments.

Methods

The murine Colon26 (C26) adenocarcinoma xenograft model was used to study the metabolic derangements associated with canc

SUBMITTER: Pin F 

PROVIDER: S-EPMC6438345 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature