Lack of muscle mTOR kinase activity causes early onset myopathy and compromises whole-body homeostasis.

ABSTRACT:

Background

The protein kinase mechanistic target of rapamycin (mTOR) controls cellular growth and metabolism. Although balanced mTOR signalling is required for proper muscle homeostasis, partial mTOR inhibition by rapamycin has beneficial effects on various muscle disorders and age-related pathologies. Besides, more potent mTOR inhibitors targeting mTOR catalytic activity have been developed and are in clinical trials. However, the physiological impact of loss of mTOR catalytic activity in skeletal muscle is currently unknown.

Methods

We have generated the mTORmKOKI mouse model in which conditional loss of mTOR is concomitant with expression of kinase inactive mTOR in skeletal muscle. We performed a comparative phenotypic and biochemical analysis of mTORmKOKI mutant animals

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6438346 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature