Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding.

ABSTRACT: Polycomb group proteins are transcriptional repressors controlling gene expression patterns and maintaining cell type identity. The chemical modifications of histones and DNA caused by the regulated activity of chromatin-modifying enzymes such as Polycomb help establish and maintain such expression patterns. Polycomb repressive complex 2 (PRC2) is the only known methyltransferase specific for histone H3 lysine 27 (H3K27) and catalyzes its trimethylation leading to the repressive H3K27me3 mark. Structural biology has made important contributions to our understanding of the molecular mechanisms that ensure the spatiotemporal regulation of PRC2 activity and the establishment of inactive chromatin domains marked by H3K27me3. In this review, we discuss the recent structural studies that have ad

SUBMITTER: Kasinath V 

PROVIDER: S-EPMC6438374 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature