Toward direct MRI of neuro-electro-magnetic oscillations in the human brain.

ABSTRACT:

Purpose

Neuroimaging techniques are widely used to investigate the function of the human brain, but none are currently able to accurately localize neuronal activity with both high spatial and temporal specificity. Here, a new in vivo MRI acquisition and analysis technique based on the spin-lock mechanism is developed to noninvasively image local magnetic field oscillations resulting from neuroelectric activity in specifiable frequency bands.

Methods

Simulations, phantom experiments, and in vivo experiments using an eyes-open/eyes-closed task in 8 healthy volunteers were performed to demonstrate its sensitivity and specificity for detecting oscillatory neuroelectric activity in the alpha-band (8-12 Hz). A comprehensive postprocessing procedure was designed to enhance the neur

SUBMITTER: Truong TK 

PROVIDER: S-EPMC6438626 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature