Histone H3 trimethylation at lysine 36 guides m⁶A RNA modification co-transcriptionally.

ABSTRACT: DNA and histone modifications have notable effects on gene expression¹. Being the most prevalent internal modification in mRNA, the N⁶-methyladenosine (m⁶A) mRNA modification is as an important post-transcriptional mechanism of gene regulation^2-4 and has crucial roles in various normal and pathological processes^5-12. However, it is unclear how m⁶A is specifically and dynamically deposited in the transcriptome. Here we report that histone H3 trimethylation at Lys36 (H3K36me3), a marker for transcription elongation, guides m⁶A deposition globally. We show that m⁶A modifications are enriched in the vicinity of H3K36me3 peaks, and are reduced globally when cellular H3K36me3 is depleted. Mechanistically, H3K

SUBMITTER: Huang H 

PROVIDER: S-EPMC6438714 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature