Epithelial-to-mesenchymal transition status of primary breast carcinomas and its correlation with metastatic behavior.

ABSTRACT:

Background

Epithelial-to-mesenchymal transition (EMT) has been implicated as an important step in the development of distant metastases. We therefore wished to study EMT status of primary breast carcinomas from patients who during follow-up developed distant metastases.

Methods

mRNA expression profiles of primary breast carcinoma samples (n = 151) from patients who developed metastatic disease were analyzed and EMT status was designated using a previously described EMT-core signature. EMT status of the primary tumor was correlated to clinicopathological characteristics, molecular subtypes, metastasis pattern, chemotherapy response and survival outcomes. In addition, using immunohistochemistry, the expression levels of several proteins implicated in EMT were studied (CDH1, CD

SUBMITTER: Savci-Heijink CD 

PROVIDER: S-EPMC6438946 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature