Resting state connectivity best predicts alcohol use severity in moderate to heavy alcohol users.

ABSTRACT: BACKGROUND:In the United States, 13% of adults are estimated to have alcohol use disorder (AUD). Most studies examining the neurobiology of AUD treat individuals with this disorder as a homogeneous group; however, the theories of the neurocircuitry of AUD call for a quantitative and dimensional approach. Previous imaging studies find differences in brain structure, function, and resting-state connectivity in AUD, but few use a multimodal approach to understand the association between severity of alcohol use and the brain differences. METHODS:Adults (ages 22-60) with problem drinking patterns (n = 59) completed a behavioral and neuroimaging protocol at the National Institutes of Health. Alcohol severity was quantified with the Alcohol Use Disorders Identification Test (AUDIT). In a 3 T MRI

SUBMITTER: Fede SJ 

PROVIDER: S-EPMC6438989 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature