The role of N⁶-methyladenosine RNA methylation in the heat stress response of sheep (Ovis aries).

ABSTRACT: With the intensive development of the sheep industry and increasing global temperatures, heat stress in sheep has become an increasingly severe and important issue in recent years. The level of N⁶-methyladenosine (m⁶A) RNA methylation changes in response to stress plays important roles in stress responses. However, the role of m⁶A in the heat stress response of sheep remains unclear. To explore this issue, we measured heat stress protein (HSP) expression, liver function indexes, m⁶A on RNA, m⁶A-related enzyme expression, and tissue damage in sheep that had been subjected to heat stress. At the transcriptome level, our results showed significant increases in m⁶A on RNA and increased mRNA levels of HSPs (HSP70, HSP90, and HSP1

SUBMITTER: Lu Z 

PROVIDER: S-EPMC6439051 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature