NMR resonance assignments of the pathogenesis-related peach allergen Pru p 1.0101.

ABSTRACT: In Europe, Northern America, and China a large number of individuals are suffering from peach (Prunus persica) allergy caused by the protein Pru p 1. Immunologic reactions against this 17.5 kDa protein result from initial sensitization to the birch (Betula verrucosa) pollen allergen Bet v 1 and subsequent immunologic cross-reactivity of Bet v 1 specific antibodies. Allergic symptoms typically include severe itching, scratching of the throat, and rhino conjunctivitis. So far, experimental structural data for the peach allergen Pru p 1 are not available. In a first step towards the elucidation of the structure of this protein we assigned backbone and side chain ¹H, ¹³C, and ¹⁵N chemical shifts of the naturally occurring isoform Pru p 1.0101 by solution NMR sp

SUBMITTER: Fuhrer S 

PROVIDER: S-EPMC6439177 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature