Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract.

ABSTRACT: Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Liquid crystal encapsulation of ciprofloxacin significantly enhanced its bactericidal efficacy and reduced cell toxicity. Liquid crystal structures are low-cost, simple to manufactu

SUBMITTER: Pisano S 

PROVIDER: S-EPMC6439215 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature