RNA interference-mediated knockdown of voltage-gated sodium channel (MpNa_v) gene causes mortality in peach-potato aphid, Myzus persicae.

ABSTRACT: Voltage-gated sodium channels (VGSC) are transmembrane proteins that generate an action potential in excitable cells and play an essential role in neuronal signaling. Since VGSCs play a crucial role in nerve transmission they have become primary targets for a broad range of commercial insecticides. RNA interference (RNAi) is a valuable reverse genetics tool used in functional genomics, but recently, it has also shown promise as a novel agent that could be used to control agricultural insect pests. In this study, we targeted the VGSC (MpNa_v) gene in the peach-potato aphid Myzus persicae, by oral feeding of artificial diets mixed with dsRNAs. Knock-down of MpNa_v gene expression caused up to 65% mortality in 3^rd instar nymphs. Moreover, significantly lower fec

SUBMITTER: Tariq K 

PROVIDER: S-EPMC6439219 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature