Tau PET in autosomal dominant Alzheimer's disease: relationship with cognition, dementia and other biomarkers.

ABSTRACT: Tauopathy is a hallmark pathology of Alzheimer's disease with a strong relationship with cognitive impairment. As such, understanding tau may be a key to clinical interventions. In vivo tauopathy has been measured using cerebrospinal fluid assays, but these do not provide information about where pathology is in the brain. The introduction of PET ligands that bind to paired helical filaments provides the ability to measure the amount and distribution of tau pathology. The heritability of the age of dementia onset tied to the specific mutations found in autosomal dominant Alzheimer's disease families provides an elegant model to study the spread of tau across the course of the disease as well as the cross-modal relationship between tau and other biomarkers. To better understand the pathobiol

SUBMITTER: Gordon BA 

PROVIDER: S-EPMC6439328 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature