Population Pharmacogenomics for Precision Public Health in Colombia.

ABSTRACT: While genomic approaches to precision medicine hold great promise, they remain prohibitively expensive for developing countries. The precision public health paradigm, whereby healthcare decisions are made at the level of populations as opposed to individuals, provides one way for the genomics revolution to directly impact health outcomes in the developing world. Genomic approaches to precision public health require a deep understanding of local population genomics, which is still missing for many developing countries. We are investigating the population genomics of genetic variants that mediate drug response in an effort to inform healthcare decisions in Colombia. Our work focuses on two neighboring populations with distinct ancestry profiles: Antioquia and Chocó. Antioquia has primarily E

SUBMITTER: Nagar SD 

PROVIDER: S-EPMC6439339 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature