GLCCI1 rs37973 is associated with the response of adrenal hormone to inhaled corticosteroids in asthma.

ABSTRACT:

Background

Previous studies have demonstrated that glucocorticoid-induced transcript 1 gene (GLCCI1) rs37973 mutant genotype is associated with poor inhaled corticosteroid (ICS) response in asthmatics. As human airway relaxation is regulated by circulation epinephrine, which can be enhanced by corticosteroid. It is unknown whether or not GLCCI1 rs37973 is associated with circulation epinephrine and cortisol concentrations in asthma. The aim of this study is to evaluate these relationships.

Methods

A total of 182 asthmatics and 180 healthy controls were recruited for the study. 30 mild-to-moderate asthmatics received fluticasone propionate (125 μg, bid) treatment for 12 weeks. GLCCI1 rs37973 genotyping was performed with the iPlex MassARRAY genotyping pla

SUBMITTER: Xun Q 

PROVIDER: S-EPMC6439416 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature